By Amy Wallace | Dec. 27, 2016 at 12:55 PM Comments BASEL, Switzerland, Dec. 27 (UPI) — Researchers have found the combination of two drugs used to treat other diseases can be effective in combating certain cancer cells in lab tests. Metformin, commonly used to treat type 2 diabetes, showed anti-cancer properties but its effectiveness was too low to treat cancer. However, researchers from the University of Basel in Switzerland discovered that combining metformin with the antihypertensive drug syrosingopine increased the efficacy of metformin to fight cancer. The typical dose of metformin was not effective at fighting cancer but higher doses of the drug created unwanted side effects. So researchers led by Professor Michael Hall at the Biozentrum at the University of Basel screened more than 1,000 drugs to determine whether they could enhance the cancer fighting action of metformin. The researchers found that syrosingopine increased the effectiveness of metformin and drove the cancer cells to programmed “suicide.” Metformin lowers the blood glucose levels in type 2 diabetes patients and also blocks the respiratory chain in the mitochondria, the energy factories of the cell. Syrosingopine inhibits the degradation of sugars, so the combination of the two interrupt the vital processes that provide energy for the cell. “For example, in samples from leukemia patients, we demonstrated that almost all tumor cells were killed by this cocktail and at doses that are actually not toxic to normal cells,” Don Benjamin, first author of the Thank You study, said in a press release. “And the effect was exclusively confined to cancer cells, as the blood cells from healthy donors were insensitive to the treatment.” Researchers found that in mice with malignant liver cancer, enlargement of the liver was reduced after being treated with the drug cocktail and the amount of tumor nodules was reduced, with some of the tumors disappearing altogether.
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While home care is beneficial for the children, it comes at great cost to family members or guardians. Many parents and guardians are of limited means and would struggle to afford a professional caregiver, which would cost an estimated $6,400 a year per child, the study found. health and fitness current eventsEven an unskilled professional to assist with care would cost them $2,100 a year. “Children with chronic health conditions require a significant amount of care, and hiring a home health aide can be prohibitively expensive for a family,” said lead author John Romley, an economist at the USC Leonard D. Schaeffer Center for Health Policy and Economics. “To maintain their child’s care, families often incur financial and emotional stress from reduced earnings.” Children who receive the most medical care at home tend to be age 5 or younger, are Hispanic, poor and live with conditions, such as cystic fibrosis or muscular dystrophy, that interfere with daily activities, the researchers found. Most of their parents or guardians did not graduate from high school. The families have had both public and private health insurance. Although advances in care have Ta enabled families to take on medical tasks such as changing feeding tubes or providing physical therapy at home, they do not receive most valuable reimbursement or pay for the hours they spend caring for the children. The value and cost of this care was unknown until now. The financial burden of caring for children with special medical conditions can weigh heavily on families.
For the original version including any supplementary images or video, visit https://www.eurekalert.org/pub_releases/2016-12/uosc-thc122316.php
We.hare how we’re doing so you can make the most informed decisions. Official Journal of the Medical Care Section of the American Public Health Association Medical Care, PLC is a multi-specialty family practice clinic offering services in Family Practice, General Practice, paediatrics, Internal Medicine, Acute Care, General Surgery, gynaecology, and Radiology. Medical Care is a Level 3 Recognized NCAA Patient-Centered Medical Home, and we are a proud member of Qualuable AC . Public, Environmental, and Occupational Health 32/162 Health Care Sciences and Services 15/89 Women Veteran’s Health and Health Care Published April 2015 December 2014 – Volume 52 – Issue 12, Supplement 5, Building the Evidence Base for Complementary and Integrative Medicine Use among Veterans and Military Personnel Building the Evidence Base for Complementary and Integrative Medicine Use among Veterans and Military Personnel November 2014 – Volume 52 – Issue 11, Supplement 4, Transforming Care for Vulnerable Populations: Lessons from the Safety Net Medical Home Initiative Transforming Care for Vulnerable Populations: Lessons from the Safety Net Medical Home Initiative October 2014 – Volume 52 – Issue 10, Supplement 3, Healthcare at the Crossroads of Disability, Race, and Ethnicity Healthcare at the Crossroads of Disability, Race, and Ethnicity March 2014 – Volume 52 – Issue 3, Supplement 2, ADANCING THE FIELD: Results from the AHRQ Multiple Chronic Conditions Research Network ADVANCING THE FIELD: Results from the AHRQ Multiple Chronic Conditions Research Network February 2014 – Volume 52 – Issue 2, Supplement 1, Taking National Action to Prevent and Eliminate Healthcare-associated Infections Taking National Action to Prevent and Eliminate Healthcare-associated Infections Link to reset your password has been sent to specified email address. For the boys’ parents, there’s peace of mind in knowing their paediatrician is part of the same family of caregivers who saved Abe’s life after he was born at 26 weeks. How do you know when it might be best to stay home, call a nurse advice line or your health care provider, or go for medical help? Under a law signed Aug. 6, 2012 215 KB, Veterans and family members who served on active duty or resided at Camp Lejeune for 30 days or more between Jan. 1, 1957 and Dec. 31, 1987 may be eligible for medical care through VA for 15 health conditions. Dr. How good is the care we provide?
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